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Postion:Product Catalog >ZD7288
ZD7288
  • ZD7288

ZD7288 NEW

Price $30 $46 $80
Package 2mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: ZD7288 CAS No.: 133059-99-1
Purity: 99.99% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameZD7288
DescriptionZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
Cell ResearchCultured hippocampal neurons were incubated with 1 μM Fura-2 acetoxy-methylol ester for 30 minutes at 37°C, washed three times with artificial cerebrospinal fluid (containing 140 mM NaCl, 5 mM KCl, 2 mM CaCl2, 1 mM MgCl2, 10 mM glucose and 10 mM hydroxyethyl piperazine ethanesulfonic acid, pH 7.3), and then incubated at room temperature in the dark for 30 minutes.?Fura-2 fluorescence was observed by a Ratio Vision digital fluorescence microscopy system.?Fluorescence signals were evoked by 340 and 380 nm excitation wavelengths and collected at 510 nm by TILLvisION 4.0 software.?The 340:380 nm fluorescence ratio was used to represent [Ca2+]i.?Peak calcium change was represented as the percentage increase from baseline.?Neurons were incubated in ZD7288 (25, 50 or 100 μM) or 8-Br-cAMP (5 or 50 μM) for 15 minutes prior to stimulation with 50 μM glutamate.?All experiments were repeated in triplicate, using different batches of cells across 4–5 dishes[1].
In vitroZD7288 attenuated glutamate-induced rises in [Ca(2+)]i in a concentration-dependent manner and reversed 8-Br-cAMP-mediated facilitation of these glutamate-induced [Ca(2+)]i rises.?ZD7288 inhibits hippocampal synaptic plasticity both glutamate release and resultant [Ca(2+)]i increases in rat hippocampal neurons[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+90% Saline : 10 mg/mL (34.15 mM), Solution.
DMSO : 225 mg/mL (768.42 mM), Sonication is recommended.
H2O : 50 mg/mL (170.76 mM), Sonication is recommended.
KeywordsZD-7288 | ZD7288 | ZD 7288 | Inhibitor | inhibit | ICI D-7288 | ICI D 7288 | Hyperpolarization activated cyclic nucleotide gated channels | HCNChannel | HCN Channel
Inhibitors Related8-Pcpt-cGMP sodium | BPU-11 | pan-HCN-IN-1 | YM758 | MS7710 | Alinidine | Cilobradine hydrochloride | Zatebradine hydrochloride | 8-Pcpt-cGMP | Ivabradine hydrochloride | RO-275 | Sp-8-Br-cGMPS
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Hypertension Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Address: 36 Washington Street, Wellesley Hill, MA
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