Zileuton NEW
| Price | $44 | $61 | $87 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-15 |
Product Details
| Product Name: Zileuton | CAS No.: 111406-87-2 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2026/06/15 |
Product Introduction
Bioactivity
| Name | Zileuton |
| Description | Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. |
| In vitro | Zileuton inhibited PGE2 production in lipopolysaccharide-stimulated human whole blood. In rat carrageenan gum-induced pleurisy, Zileuton decreased PGE2 and 6-ketoprostaglandin F1α pleural levels. In activated mouse peritoneal macrophages and macrophage J774, Zileuton significantly reduced PGE2 and 6-keto prostaglandin F1α levels. In macrophages, Zileuton inhibited PG biosynthesis by interfering with arachidonic acid release. |
| In vivo | Zileuton inhibited PGE2 production in lipopolysaccharide-stimulated human whole blood. In rat carrageenan gum-induced pleurisy, Zileuton decreased PGE2 and 6-ketoprostaglandin F1α pleural levels. In activated mouse peritoneal macrophages and macrophage J774, Zileuton significantly reduced PGE2 and 6-keto prostaglandin F1α levels. In macrophages, Zileuton inhibited PG biosynthesis by interfering with arachidonic acid release. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 126 mg/mL (533.24 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (42.32 mM), Sonication is recommended. |
| Keywords | Zileuton | LOX | Lipoxygenase | Inhibitor | inhibit | Ferroptosis | COX-1 | Abbott-64077 | Abbott64077 | A-64077 | A64077 | 5-Lipoxygenase |
| Inhibitors Related | Hemin | Caffeic Acid | Acetaminophen | L-Glutamic acid | Sorafenib | Curcumin | L-Cystine | L-Glutamine | (-)-Epigallocatechin Gallate | Trometamol | Sodium Molybdate | Magnesium sulfate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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