ZYZ-488 NEW
| Price | $297 | $987 | $1360 |
| Package | 5mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: ZYZ-488 | CAS No.: 1470302-79-4 |
| Purity: 99.04% | Supply Ability: 10g |
| Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | ZYZ-488 |
| Description | ZYZ-488 is an Apoptotic Protease-Activating Factor 1 (Apaf-1) inhibitor that inhibits the activation of procaspase-9 and procaspase-3. It can be used to study cardiovascular diseases. |
| In vitro | ZYZ-488 is a novel inhibitor of apoptotic protease activator 1 (Apaf-1). The main mechanism is that ZYZ-488 binds directly to Apaf-1, thus blocking the recruitment of procaspase-9 by Apaf-1. [1] |
| In vivo | Intramuscular injection of ZYZ-488 (33.9 mg/kg or 67.8 mg/kg) in mice reduced the MI-induced increase in left ventricular volume and reduced the thickness of the ventricular wall. ZYZ-488 preserves cardiac function in a dose-dependent manner. [1] [2] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 80 mg/mL (164.12 mM), Sonication is recommended. DMSO : 180 mg/mL (369.26 mM), Sonication is recommended. |
| Keywords | ZYZ-488 | ZYZ 488 | Apoptotic protease activating factor-1 |
| Inhibitors Related | Taurodeoxycholic acid | Allethrin | SKLB-163 | Z-VAD(OMe)-FMK | Fenbufen | Cystamine | Tauroursodeoxycholate sodium | (Iso)-Z-VAD(OMe)-FMK | CIL62 | Tauroursodeoxycholate | Allicin | PAC-1 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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