Hinokitiol synthesis
- Product Name:Hinokitiol
- CAS Number:499-44-5
- Molecular formula:C10H12O2
- Molecular Weight:164.2
Yield:499-44-5 97.5%
Reaction Conditions:
with potassium phosphate in tetrahydrofuran at 100; for 2 h;
Steps:
11 Example 11
2-hydroxy-4-chloro-2,4,6-cycloheptatrien-1-one 15.6 g (0.1 mol) was added to 600 mL of THF, and then 1 mol/L of potassium phosphate 330 mL and isopropylboric acid (0.12 mol) were added, and the mixture was heated to 100 ° C, After the reaction was carried out for 2 h, the mixture was extracted and concentrated with ethyl acetate, then it was added to 300 mL of methanol and 300 mL of HCl/1,4-dioxane 300 mL, and reacted at room temperature for 5 h, and the reaction of the raw materials was monitored by TLC. It was concentrated in vacuo and washed with diethyl ether to give Hinokitiol 16g. yield 97.5%.
References:
CN108586215,2018,A Location in patent:Paragraph 0060; 0061
4570-11-0
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