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Neostigmine Bromide

Catalog No.
B1594
Cholinesterase inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL H2O)
$50.00
In stock
100mg
$65.00
In stock
500mg
$120.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Neostigmine bromide is a reversible inhibitor of acetylcholinesterase.[1]

AChE (acetylcholinesterase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine at the neuromuscular junction and cholinergic synaspe. It terminates the signal transductions and plays a role in neuronal apoptosis.

Neostigmine bromide is a quaternary amine that blocked cholinesterase activity to extend and enhance the muscarinic and nicotinic effects of acetylcholine. It is implicated for the treatment of primary open-angle glaucoma, postoperative urinary retention, paralytic ileus, myasthenia gravis etc. It is also reported to be an adjuvant to local anaesthetics and opioids for post-surgical pain after gynaecological or abdominal surgery. [1]

Reference:
[1] El-Kosasy AM, Nebsen M, Abd El-Rahman MK, Salem MY, El-Bardicy MG.  Comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide.  Talanta. 2011 Aug 15;85(2):913-8. 

Chemical Properties

Physical AppearanceA solid
StorageStore at -20°C
M.Wt303.2
Cas No.114-80-7
FormulaC12H19N2O2·Br
Solubility≥15.16 mg/mL in H2O; ≥29.2 mg/mL in EtOH; ≥45.3 mg/mL in DMSO
Chemical Name[3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium;bromide
Canonical SMILESCN(C)C(Oc1cc([N+](C)(C)C)ccc1)=O.[Br-]
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Neostigmine Bromide
 

User Guide

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