一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Toggle Nav
Close
  • Menu
  • Setting

AG-82

Catalog No.
C4760
inhibitor of EGFR kinase
Grouped product items
SizePriceStock Qty
25mg
$175.00
Ship with 5-10 days
50mg
$311.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

AG-82 is a cell-permeable, reversible, and competitive inhibitor of tyrosine kinase and epidermal growth factor (EGF) receptor.

Protein tyrosine kinases (PTKs) have been involved in regulating cell proliferation, cell differentiation, and signaling processes in the immune system. Dysfunction of protein tyrosine kinases result in inflammatory responses and diseases including cancer, atherosclerosis, and psoriasis [2]. The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein. Activation of EGFR results in autophosphorylation of receptor tyrosine kinase and has been involved in regulating cellular proliferation, differentiation, and survival. Overexpression of EGFR has been identified in a variety of tumor cell lines and has been associated with poor prognosis and decreased survival [3].

In the human epidermoid carcinoma cell line A431, AG-82 inhibited the activity of epidermal growth factor receptor kinase with an IC50 value of 3 μM [1]. AG-82 inhibited the GTPase activity of transducin with an IC50 of 7 μM. AG-82 inhibited neuromedin B-induced phosphorylation of p125FAK (focal adhesion kinase). AG-82 blocked the induction of inducible nitric oxide synthase in glial cells and Induced apoptosis in human leukemic cell lines.

References:
[1] Gazit A, Yaish P, Gilon C, et al.? Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors[J]. Journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[2] Levitzki A, Gazit A.? Tyrosine kinase inhibition: an approach to drug development[J]. Science, 1995, 267(5205): 1782.
[3] Herbst R S.? Review of epidermal growth factor receptor biology[J]. International Journal of Radiation Oncology Biology Physics, 2004, 59(2): S21-S26.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt202.2
Cas No.118409-58-8
FormulaC10H6N2O3
SynonymsNSC 676484,RG-50875,Tyrphostin 25,Tyrphostin AG-82
Solubility≤20mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name2-[(3,4,5-trihydroxyphenyl)methylene]-propanedinitrile
Canonical SMILESN#CC(C#N)=Cc(cc1O)cc(O)c1O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

AG-82
 

User Guide

赞皇县| 彩票| 吉木乃县| 海安县| 舒兰市| 双城市| 阿鲁科尔沁旗| 和平区| 龙门县| 岫岩| 花垣县| 滨海县| 凤庆县| 建德市| 定安县| 惠东县| 平顶山市| 玛沁县| 五大连池市| 蓬安县| 横山县| 通海县| 临湘市| 濮阳市| 绥芬河市| 汾西县| 楚雄市| 黄平县| 慈溪市| 永宁县| 龙泉市| 泗阳县| 周宁县| 澄江县| 弥勒县| 留坝县| 扎兰屯市| 蓬安县| 绥江县| 渝北区| 贞丰县|