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L-689,560

Catalog No.
B6430
potent NMDA antagonist
Grouped product items
SizePriceStock Qty
10mg
$548.00
In stock
50mg
$1,775.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

L-689,560 (CAS: 139051-78-8) is a potent antagonist selective for the glycine-binding site of the NMDA receptor, with an affinity (K_b) of 130 nM. This tetrahydroquinoline derivative preferentially inhibits NMDA receptor activity via blockade at the glycine site, demonstrating over three orders of magnitude selectivity compared to glutamate site targeting. L-689,560 radiolabeled analogues ([^3H]-L-689,560) are utilized as highly selective ligands for studying glycine site interactions in vitro. This compound serves as an experimental tool in neurological research, particularly in models investigating ischemic cerebral damage and seizure susceptibility. No clinical studies have been reported.

Chemical Properties

Physical AppearanceWhite solid
StorageStore at RT
M.Wt380.23
Cas No.139051-78-8
FormulaC17H15Cl2N3O3
Solubility≥20.9 mg/mL in DMSO; ≥42 mg/mL in EtOH; insoluble in H2O
Chemical Name(2S,4S)-5,7-dichloro-4-(3-phenylureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid
Canonical SMILESOC([C@H](C1)Nc2cc(Cl)cc(Cl)c2[C@H]1NC(Nc1ccccc1)=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

User Guide

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