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5,15-DPP

Catalog No.
C3975
STAT3 inhibitor
Grouped product items
SizePriceStock Qty
25mg
$149.00
Ship with 5-10 days
50mg
$244.00
Ship with 5-10 days
100mg
$393.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

5,15-diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist [1].

Stat3 is constitutively activated in many human cancers. Stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. Aberrant STAT3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].

In vitro: 5,15-DPP directly bound to STAT3 and antagonized the function of STAT3-SH2. 5,15-DPP selectively antagonized STAT3-SH2 with an IC50 of 0.28 μM over the other SH2-containing proteins STAT1 and Grb2[1]. The estimated KD values for the 5,15-DPP binding to STAT3 was 880 nM. Treatment with 5,15-DPP suppressed the DNA binding activity of STAT3 in a concentration-dependent manner. 5,15-DPP poorly inhibited STAT1 with an IC50 of 10 μM and showed no effect Grb2 [1].

References:
[1] Uehara Y, Mochizuki M, Matsuno K, et al.? Novel high-throughput screening system for identifying STAT3–SH2 antagonists[J]. Biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] Jing N, Tweardy D J.? Targeting Stat3 in cancer therapy[J]. Anti-cancer drugs, 2005, 16(6): 601-607.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt462.6
Cas No.22112-89-6
FormulaC32H22N4
Synonyms5,15-Diphenylporphyrin,STAT3 Inhibitor VIII
Solubility≤2mg/ml in dimethyl formamide
Chemical Name5,15-diphenyl-21H,23H-porphine
Canonical SMILESc1c(/C=C(/C=C2)\N=C2/C(\c2ccccc2)=C(/C=C2)\N/C\2=C\C(C=C2)=N/C\2=C2/c3ccccc3)[nH]c/2c1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

5,15-DPP
 

User Guide

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