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Cyclothiazide

Catalog No.
B6415
positive allosteric modulator of AMPA receptors
Grouped product items
SizePriceStock Qty
10mg
$86.00
In stock
50mg
$376.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Cyclothiazide (CAS No.: 2259-96-3) is a thiazide compound that was initially introduced into clinical use as a diuretic and antihypertensive drug. Subsequent studies have found that it has significant neuromodulatory effects, particularly as a positive allosteric modulator of AMPA receptors, effectively inhibiting AMPA receptor desensitization and enhancing current responses. AMPA receptors are composed of the GluR-1, GluR-2, GluR-3, and GluR-4 subunits, and Cyclothiazide is selective for the flip variants of these subunits. In vitro studies show that Cyclothiazide can significantly enhance AMPA receptor-mediated synaptic transmission at nanomolar to low micromolar concentrations. The dose or concentration used in experiments typically depends on the experimental design and research objectives. In cellular and animal models, Cyclothiazide is commonly used to study AMPA receptor function, synaptic plasticity, and mechanisms related to neurodegenerative diseases. In addition, in drug screening studies, Cyclothiazide is used as a reference compound to evaluate the potency and selectivity of other AMPA receptor modulators.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at RT
M.Wt389.87
Cas No.2259-96-3
FormulaC14H16ClN3O4S2
Solubilityinsoluble in EtOH; insoluble in H2O; ≥14 mg/mL in DMSO
Chemical Name3-(bicyclo[2.2.1]hept-5-en-2-yl)-6-chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
Canonical SMILESO=S(=O)(N)C=1C=C2C(=CC1Cl)NC(NS2(=O)=O)C3CC4C=CC3C4
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Chemical structure

Cyclothiazide
 

User Guide

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