一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Toggle Nav
Close
  • Menu
  • Setting

Myoseverin

Catalog No.
B6076
microtubule-binding molecule
Grouped product items
SizePriceStock Qty
5mg
$109.00
Ship with 5-10 days
10mg
$189.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50: 16 nM

Myoseverin is a novel microtubule-binding molecule.

Microtubules are dynamic filamentous cytoskeletal proteins, which are composed of tubulin and are an critical therapeutic target in tumour cells. Drugs binding to microtubules have been the first-line standard of anticancer therapy for decades and until the advent of targeted therapy.

In vitro: Myoseverin was found to be able to induce the reversible fission of multinucleated myotubes into mononucleated fragments. In addition, cell proliferation and myotube fission promoted DNA synthesis after myoseverin removal and transfer of the cells to the fresh growth medium. Moreover, the biochemical analysis and transcriptional profiling showed that myoseverin alone did not reverse the processes of biochemical differentiation. However, myoseverin could affect the expression of various growth factor, extracellular matrix-remodeling, immunomodulatory, as well as stress response genes, which was consistent with the activation of pathways involved in tissue regeneration and wound healing [1]. Another study found that myoseverin-treated cardiac myocytes showed disruptions of the striated Z-bands with alpha-actinin and desmin. Similarly, active stathmin expression did not prevent the assembly of sarcomere. Moreover, the extent of MT destabilization caused by myoseverin and nocodazole were comparable [2].

In vivo: Currently, there is no animal in vivo data reported.

Clinical trial: Up to now, myoseverin is still in the preclinical development stage.

References:
[1] Rosania GR,Chang YT,Perez O,Sutherlin D,Dong H,Lockhart DJ,Schultz PG.  Myoseverin, a microtubule-binding molecule with novel cellular effects. Nat Biotechnol.2000 Mar;18(3):304-8.
[2] Ng DC,Gebski BL,Grounds MD,Bogoyevitch MA.  Myoseverin disrupts sarcomeric organization in myocytes: an effect independent of microtubule assembly inhibition. Cell Motil Cytoskeleton.2008 Jan;65(1):40-58.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt432.52
Cas No.267402-71-1
FormulaC24H28N6O2
SolubilitySoluble in DMSO
Chemical Name(E)-9-isopropyl-N-(4-methoxybenzyl)-2-((4-methoxybenzyl)imino)-2,9-dihydro-1H-purin-6-amine
Canonical SMILESCC(C)N(C=NC1=C(NCc(cc2)ccc2OC)N2)C1=N/C\2=N/Cc(cc1)ccc1OC
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Myoseverin
 

User Guide

辽阳市| 内乡县| 抚远县| 兴仁县| 兴山县| 南岸区| 恭城| 宜都市| 太原市| 榆树市| 东海县| 巨鹿县| 安顺市| 星子县| 马公市| 林州市| 山阴县| 金堂县| 桃江县| 刚察县| 汤阴县| 皋兰县| 泰兴市| 钦州市| 宜兰市| 遂昌县| 长沙县| 定结县| 壶关县| 菏泽市| 积石山| 张家港市| 洛川县| 邹平县| 汾阳市| 开化县| 清新县| 嵊州市| 上栗县| 邢台县| 霍林郭勒市|