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(R)-(+)-Atenolol

Catalog No.
C3031
less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol.
Grouped product items
SizePriceStock Qty
5mg
$78.00
Ship with 5-10 days
10mg
$131.00
Ship with 5-10 days
25mg
$252.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

(R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R, S)-atenolol [1].

Atenolol is a selective β1 receptor antagonist, a drug belonging to the group of beta blockers, a class of drugs used primarily in cardiovascular diseases. Atenolol is used for a number of conditions including hypertension, angina, long QT syndrome, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, and the symptoms of alcohol withdrawal. β1-adrenergic receptor is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac tissue.

Pharmacokinetic data of the time course of plasma concentrations over 24 h following oral administration of 50 mg (R)-(+)-Atenolol revealed that the Cmax, AUC, and t1/2 values were 326±87 ng/ml, 2599±639 ng×h/ml, and 8.9±2.9 h, respectively [1].

Reference:
[1] Stoschitzky K, Egginger G, Zernig G, et al.  Stereoselective features of (R)- and (S)-atenolol: clinical pharmacological, pharmacokinetic, and radioligand binding studies[J]. Chirality, 1993, 5(1): 15-19.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt266.3
Cas No.56715-13-0
FormulaC14H22N2O3
Solubility≤5mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide
Chemical Name4-[(2R)-2-hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneacetamide
Canonical SMILESCC(C)NC[C@H](COc1ccc(CC(N)=O)cc1)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

(R)-(+)-Atenolol
 

User Guide

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