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Paxilline

Catalog No.
B6920
high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels blocker
Grouped product items
SizePriceStock Qty
5mg
$183.00
Ship with 5-10 days
10mg
$333.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Paxilline (CAS: 57186-25-1) is a fungal-derived indole diterpene recognized primarily for its potent, reversible blockade of large-conductance calcium-activated potassium (BKCa or KCa1.1) channels. By interacting with these channels, paxilline increases the binding affinity of charybdotoxin, a neurotoxic peptide, to BKCa ion channels. Additionally, it inhibits sarco/endoplasmic reticulum Ca2? ATPase (SERCA) activity at micromolar concentrations (IC50 range: 5–50 μM). Given these bioactivities, paxilline serves as a valuable pharmacological tool for investigating calcium-dependent potassium channel physiology and calcium homeostasis in cellular research.

Product Citation

Chemical Properties

Physical AppearanceA crystalline solid
StorageDesiccate at -20°C
M.Wt435.56
Cas No.57186-25-1
FormulaC27H33NO4
SolubilitySoluble in DMSO
Chemical Name(2R,4bS,6aR,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
Canonical SMILESCC(C)([C@H]1O[C@@H](CC[C@](C)([C@](C)([C@@H](C2)CC3)c4c2c(cccc2)c2[nH]4)[C@@]32O)C2=CC1=O)O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Paxilline
 

User Guide

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