6-OAU
6-OAU is a synthetic agonist for GPR84.
GPR84, a Gαi protein-coupled receptor, is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is also a putative receptor for medium-chain fatty acids. GPR84 is expressed in leukocytes and its expression can be further induced by LPS.
In vitro: A previous study identified 6-OAU as a surrogate agonist for GPR84. It was found that 6-OAU and potential ligands were able to stimulate [(35)S]GTP binding and accumulate phosphoinositides in a GPR84-dependent manner. Moreover, 6-OAU could internalize GPR84-EGFP from the cell surface. In addition, results showed that both 6-OAU and the potential ligands could elicite chemotaxis of human polymorphonuclear leukocytes (PMNs) and macrophages and amplify LPS-stimulated production of the proinflammatory cytokine IL-8 from PMNs and TNFα from macrophages [1].
In vivo: Animal study found that the iv injection of 6-OAU was able to raise the blood CXCL1 level in rats. In addition, the inoculation of 6-OAU into the rat air pouch could accumulate PMNs and macrophages in the site [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Suzuki, M. ,Takaishi, S.,Nagasaki, M., et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. The Journal of Biological Chemisty 288(15), 10684-10691 (2013).
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 239.3 |
| Cas No. | 83797-69-7 |
| Formula | C12H21N3O2 |
| Solubility | ≤0.25mg/ml in DMSO;0.25mg/ml in dimethyl formamide |
| Chemical Name | 6-(octylamino)-2,4(1H,3H)-pyrimidinedione |
| Canonical SMILES | CCCCCCCCNC(NC(N1)=O)=CC1=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
