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OF-1

Catalog No.
B4895
BRPF1B and BRPF2 bromodomain inhibitor
Grouped product items
SizePriceStock Qty
10mM (in 1mL DMSO)
$83.00
In stock
5mg
$75.00
In stock
25mg
$267.00
In stock
100mg
$652.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd value = 100nM and 500 nM, respectively; >100-fold selectivity over majority of other bromodomains).
BRPF (BRomodomain and PHD Finger containing) protein family are scaffolding proteins that assembles MYST histone acetyltransferase complexes. MYST complexes play important role in DNA repair, recombination, replication and transcription activation.
In cellular thermal shift assay (CETSA) of full length BRPF1B, OF-1 enhanced thermal stability at 1 µM. In BRPF2 FRAP assay, OF-1 showed accelerated FRAP recovery at 5µM. OF-1 exhibited modest general cytotoxicity.
References:
[1]. OF-1 - A chemical probe for BRPF bromodomains. (2010, October 13). SGC. Retrieved from http://www.thesgc.org/chemical-probes/OF-1

Chemical Properties

StorageStore at -20°C
M.Wt440.31
Cas No.919973-83-4
FormulaC17H18BrN3O4S
Solubilityinsoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO
Chemical Name4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide
Canonical SMILESCc(cc(cc1)Br)c1S(Nc(cc(c(N1C)c2)N(C)C1=O)c2OC)(=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

OF-1
 

User Guide

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