[CAS NO. 101-31-5]??L-Hyoscyamine

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PRODUCTS SPECIFICATIONS [101-31-5]

Catalog

HY-N0471

Brand

MCE

CAS

101-31-5

DESCRIPTION [101-31-5]

Overview

MDL	-
Molecular Weight	289.37
Molecular Formula	C17H23NO3
SMILES	CN1[C@@H]2C[C@@H](OC([C@@H](C3=CC=CC=C3)CO)=O)C[C@H]1CC2

For research use only. We do not sell to patients.

Summary

L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine (HY-B1205) ^[1] ^[2] .

In Vivo

L-Hyoscyamine (Daturine; 5-20 mg/kg; iv) prolongs the migrating MMC cycle length ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats ^[1]
Dosage:	5, 10, 20 mg/kg
Administration:	IV
Result:	Prolonged the migrating myoelectric complex (MMC) cycle length.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 345.58 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4558 mL	17.2789 mL	34.5578 mL
5 mM	0.6912 mL	3.4558 mL	6.9116 mL
10 mM	0.3456 mL	1.7279 mL	3.4558 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.64 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Lars G?ran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
[2] Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8.

Synonyms

Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-

1αH,5αH-Tropan-3α-ol, (-)-tropate (ester)

Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(S)-endo]-

Tropic acid, 1αH,5αH-tropan-3α-yl ester, (-)-

(-)-Atropine

Daturine

Duboisine

(-)-Hyoscyamine

l-Hyoscyamine

Hyoscyamine

1αH,5αH-Tropan-3α-yl (-)-tropate

l-Tropine tropate

(S)-(-)-Hyoscyamine

L-Hyoscyamine

L-Hyoscyamin

l-Atropine

(S)-Atropine

Cystospaz

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