一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

[CAS NO. 10129-56-3]??PETCM

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [10129-56-3]

Catalog
HY-103349
Brand
MCE
CAS
10129-56-3

DESCRIPTION [10129-56-3]

Overview

MDL-
Molecular Weight240.51
Molecular FormulaC8H8Cl3NO
SMILESOC(C(Cl)(Cl)Cl)CC1=CC=NC=C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE


Summary

PETCM is an activator of caspase-3 and acts as an cytochrome?c?(cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells [1] [2] .


IC50 & Target

Caspase 3


In Vitro

PETCM (0.1-0.5 mM) stimulates caspase-3 activity (DEVD activity) of HeLa S-100 in a dose-dependent manner.And 0.2 mM PETCM is more efficient in activating caspase-3 than 1 mM dATP [1] .
PETCM (0.2 mM; 1 hour) drives apoptosome formation. Apaf-1 in a normal HeLa cell S-100 fraction is in an inactive monomeric form. After 1 mM dATP, most of the Apaf-1 shifted to a size of 1 million daltons. After the S-100 fraction with 0.2 mM PETCM, Apaf-1 exhibits a similar shift. And the efficiency of apoptosome formation was better with 0.2 mM PETCM [1] .
PETCM (0.2 mM; 1 hour) can antagonize the inhibitory activity of ProT reduced caspase-3 activation in in HeLa cells [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis [1]

Cell Line: HeLa cells
Concentration: 0.2 mM
Incubation Time: 1 hour
Result: Increased apoptosome formation.

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 415.78 mM ; ultrasonic and heat to 40°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1578 mL 20.7892 mL 41.5783 mL
5 mM 0.8316 mL 4.1578 mL 8.3157 mL
10 mM 0.4158 mL 2.0789 mL 4.1578 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (10.39 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.39 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.39 mM); Clear solution

* All of the co-solvents are available by MCE.


台东市| 建阳市| 隆子县| 望谟县| 阳江市| 离岛区| 大荔县| 青浦区| 资阳市| 同仁县| 临安市| 浦县| 定远县| 革吉县| 苏尼特右旗| 灌南县| 建瓯市| 庆云县| 冷水江市| 武邑县| 勃利县| 江油市| 杂多县| 延庆县| 丰城市| 萨嘎县| 望谟县| 阜康市| 洛浦县| 尼勒克县| 樟树市| 茌平县| 修文县| 金川县| 柏乡县| 任丘市| 崇文区| 宜城市| 赤壁市| 东明县| 五台县|