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[CAS NO. 108-30-5]??Succinic anhydride

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PRODUCTS SPECIFICATIONS [108-30-5]

Catalog
HY-79369
Brand
MCE
CAS
108-30-5

DESCRIPTION [108-30-5]

Overview

MDLMFCD00005525
Molecular Weight100.07
Molecular FormulaC4H4O3
SMILESO=C(CC1)OC1=O

For research use only. We do not sell to patients.

Summary

Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide [1] .


IC50 & Target

Non-cleavable


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 999.30 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.9930 mL 49.9650 mL 99.9300 mL
5 mM 1.9986 mL 9.9930 mL 19.9860 mL
10 mM 0.9993 mL 4.9965 mL 9.9930 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (24.98 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

2,5-Furandione, dihydro-
Succinic anhydride
Dihydro-2,5-furandione
Butanedioic anhydride
2,5-Diketotetrahydrofuran
Succinic acid anhydride
Succinyl oxide
Tetrahydro-2,5-dioxofuran
Succinyl anhydride
Tetrahydro-2,5-furandione
Rikacid SA
NSC 8518
Oxolane-2,5-dione
Rikacid

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