[CAS NO. 124-76-5]??Isoborneol

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PRODUCTS SPECIFICATIONS [124-76-5]

Catalog

HY-N2004

Brand

MCE

CAS

124-76-5

DESCRIPTION [124-76-5]

Overview

MDL	MFCD00074821
Molecular Weight	154.25
Molecular Formula	C10H18O
SMILES	C[C@@]([C@@H]1O)(CC[C@@H]2C1)C2(C)C

For research use only. We do not sell to patients.

Summary

Isoborneol ((±)-Isoborneol) is a monoterpenoid alcohol present in the essential oils of numerous medicinal plants and has antioxidant and antiviral properties. Isoborneol is a potent inhibitor of herpes simplex virus type 1 (HSV-1) ^[1] ^[2] .

IC50 & Target

HSV-1

In Vitro

Isoborneol ((±)-Isoborneol) protects against 6-OHDA-induced increases in caspase-3 activity and cytochrome C translocation into the cytosol from mitochondria. Isoborneol prevents 6-OHDA from decreasing the Bax/Bcl-2 ratio ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 648.30 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4830 mL	32.4149 mL	64.8298 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Tian LL, Zhou Z, Zhang Q, et al. Protective effect of (+/-) isoborneol against 6-OHDA-induced apoptosis in SH-SY5Y cells. Cell Physiol Biochem. 2007;20(6):1019‐1032.
[2] Armaka M, Papanikolaou E, Sivropoulou A, Arsenakis M. Antiviral properties of isoborneol, a potent inhibitor of herpes simplex virus type 1. Antiviral Res. 1999;43(2):79‐92.

Synonyms

Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1R,2R,4R)-rel-

Isoborneol

Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, exo-

rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol

Isobornyl alcohol

exo-2-Hydroxy-1,7,7-trimethylnorbornane

2-exo-Bornyl alcohol

(±)-Isoborneol

dl-Isoborneol

DL-Isoborneol

NSC 26350

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