[CAS NO. 13171-25-0]??Trimetazidine dihydrochloride
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [13171-25-0]
Catalog
SLK-S4543
Brand
Selleck
CAS
13171-25-0
DESCRIPTION [13171-25-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 339.26 |
| Molecular Formula | C14H22N2O3.2HCl |
| SMILES | C(C1=C(OC)C(OC)=C(OC)C=C1)N2CCNCC2.Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9476 mL | 14.7380 mL | 29.4759 mL |
| 5 mM | 0.5895 mL | 2.9476 mL | 5.8952 mL |
| 10 mM | 0.2948 mL | 1.4738 mL | 2.9476 mL |
| 50 mM | 0.0590 mL | 0.2948 mL | 0.5895 mL |
Description
Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as inhibitor.
Targets
| mitochondrial long-chain 3-ketoacyl thiolase [1] (Cell-free assay) |
| 75 nM |
In vitro
Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion.
In vivo
The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia.
References
Synonyms
Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
Piperazine, 1-(2,3,4-trimethoxybenzyl)-, dihydrochloride
Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, dihydrochloride
Trimetazidine dihydrochloride
Vastarel
S 4004
1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride
Vastarel F
Yoshimilon
Kyurinett
Trivedon
Powered by Arctom Copyright ? 2026 Arctom.
All rights reserved.