[CAS NO. 13187-06-9]??Pimethixene maleate
PRODUCTS SPECIFICATIONS [13187-06-9]
DESCRIPTION [13187-06-9]
Overview
| MDL | MFCD00079242 |
|---|---|
| Molecular Weight | 409.50 |
| Molecular Formula | C23H23NO4S |
| SMILES | CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3.OC(/C=C\C(O)=O)=O |
Summary
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT 1A , 5-HT 2A , 5-HT 2B , 5-HT 2C , histamine H 1 , dopamine D 2 and D 4.4 as well as muscarinic M 1 and M 2 receptors, with pK i s of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively [1] .
IC50 & Target
|
5-HT 2B Receptor 10.44 (pKi) |
5-HT 2A Receptor 10.22 (pKi) |
5-HT 2C Receptor 8.42 (pKi) |
5-HT 1A Receptor 7.63 (pKi) |
M 2 receptor 9.38 (pKi) |
M 1 receptor 8.61 (pKi) |
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|
D 2 receptor 8.19 (pKi) |
DD 4.4 receptor 7.54 (pKi) |
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Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 244.20 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4420 mL | 12.2100 mL | 24.4200 mL |
| 5 mM | 0.4884 mL | 2.4420 mL | 4.8840 mL |
| 10 mM | 0.2442 mL | 1.2210 mL | 2.4420 mL |
Synonyms