一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

[CAS NO. 150683-30-0]??Tolvaptan

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [150683-30-0]

Catalog
SLK-S2593
Brand
Selleck
CAS
150683-30-0

DESCRIPTION [150683-30-0]

Overview

MDL-
Molecular Weight448.94
Molecular FormulaC26H25ClN2O3
SMILESC(=O)(N1C=2C(=CC(Cl)=CC2)C(O)CCC1)C3=C(C)C=C(NC(=O)C4=C(C)C=CC=C4)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.2275 mL11.1373 mL22.2747 mL
5 mM0.4455 mL2.2275 mL4.4549 mL
10 mM0.2227 mL1.1137 mL2.2275 mL
50 mM0.0445 mL0.2227 mL0.4455 mL

Description

Tolvaptan (OPC-41061) is an orally effective nonpeptide arginine antagonist with of 3 nM, used to treat hyponatremia.

Targets

vasopressin receptor 2 [4]
3 nM

In vitro

Tolvaptan blocks the binding of [(3)H]AVP to human V(2) receptors with 29-fold greater selectivity than that for V(1a) receptors, and showed no inhibition of V(1b) receptors. Tolvaptan inhibits not only the binding of [(3)H]AVP but also the AVP-induced production of cyclic AMP in human V(2)-receptor-expressing HeLa cells. Tolvaptan shows marked aquaresis in healthy and diseased animals. Tolvaptan causes a concentration-dependent inhibition of arginine vasopressin-induced cAMP production with an apparent IC(50) of 0.1 nM in autosomal dominant polycystic kidney disease (ADPKD) cells. Tolvaptan inhibits AVP-induced ERK signaling and cell proliferation. Tolvaptan inhibits AVP-induced Cl(-) secretion and decreases in vitro cyst growth of ADPKD cells cultured within a three-dimensional collagen matrix.

In vivo

Tolvaptan improves hyponatremia, resulting in the prevention of death, and improves organ water retention in rat models with acute and chronic hyponatremia. Tolvaptan reduces cardiac preload without unfavorable effects on renal functions, systemic hemodynamics, or circulating neurohormones in dogs with heart failure (HF). Tolvaptan shows a decrease in kidney weight as well as in cyst and fibrosis volume in animal models of human polycystic kidney disease (PKD). Tolvaptan markedly elevates electrolyte-free water clearance (E-CH(2)O) or aquaresis to a positive value and increases urinary Arginine vasopressin (AVP) excretion in rats with heart failure.


Synonyms

Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-
1H-1-Benzazepine, benzamide deriv.
N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
OPC 41061
Tolvaptan
Samsca
1-[4-(2-Methylbenzoylamino)-2-methylbenzoyl]-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-ol
Jynarque
Jinarc

民权县| 华亭县| 蒲城县| 蓬莱市| 上饶市| 乡宁县| 广宁县| 肃北| 汝城县| 淮南市| 始兴县| 宁陕县| 金华市| 合川市| 青海省| 米泉市| 阿巴嘎旗| 南充市| 托里县| 恭城| 基隆市| 宽甸| 太白县| 静海县| 海阳市| 永丰县| 邵武市| 嘉义县| 龙山县| 休宁县| 崇信县| 当涂县| 深泽县| 淄博市| 新宾| 安达市| 金昌市| 黎川县| 石渠县| 奈曼旗| 宜宾市|