[CAS NO. 1568-80-5]??HIV-1 integrase inhibitor 8

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PRODUCTS SPECIFICATIONS [1568-80-5]

Catalog

HY-107485

Brand

MCE

CAS

1568-80-5

DESCRIPTION [1568-80-5]

Overview

MDL	-
Molecular Weight	308.41
Molecular Formula	C21H24O2
SMILES	CC1(CC(C2=CC(O)=CC=C21)(C3)C4=CC(O)=CC=C4C3(C)C)C

For research use only. We do not sell to patients.

Summary

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8 ^[1] .

In Vitro

HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn ²⁺ as the cationic cofactor by gel assay with IC ₅₀ values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC ₅₀ value of 200 μM ^[1] .
The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC ₅₀ values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays ^[1] .
HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD ₅₀ (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 405.30 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2424 mL	16.2122 mL	32.4244 mL
5 mM	0.6485 mL	3.2424 mL	6.4849 mL
10 mM	0.3242 mL	1.6212 mL	3.2424 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.74 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.74 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.74 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem

Synonyms

1,1′-Spirobi[1H-indene]-6,6′-diol, 2,2′,3,3′-tetrahydro-3,3,3′,3′-tetramethyl-

1,1′-Spirobi[indan]-6,6′-diol, 3,3,3′,3′-tetramethyl-

2,2′,3,3′-Tetrahydro-3,3,3′,3′-tetramethyl-1,1′-spirobi[1H-indene]-6,6′-diol

3,3,3′,3′-Tetramethyl-1,1′-spirobi[indane]-6,6′-diol

6,6′-Dihydroxy-3,3,3′,3′-tetramethyl-1,1′-spirobiindane

SI (diol)

SI

3,3,3′,3′-Tetramethyl-1,1′-spiroindane-6,6′-diol

3,3,3′,3′-Tetramethyl-2,2′,3,3′-tetrahydro-1,1′-spirobi[indene]-6,6′-diol

3,3,3′,3′-Tetramethyl-1,1′-spirobiindan-6,6′-diol

3,3,3′,3′-Tetramethyl-1,1′-spirobisindane-6,6′-diol

3,3,3′,3′-Tetramethyl-1,1′-spirobisindan-6,6′-diol

3,3′-Spiro-bis(1,1-dimethyl-2,3-dihydro-1H-inden-5-ol)

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