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[CAS NO. 1670249-37-2]??Azido-PEG9-acid

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PRODUCTS SPECIFICATIONS [1670249-37-2]

Catalog
HY-130475
Brand
MCE
CAS
1670249-37-2

DESCRIPTION [1670249-37-2]

Overview

MDL-
Molecular Weight511.56
Molecular FormulaC21H41N3O11
SMILESO=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

For research use only. We do not sell to patients.

Summary

Azido-PEG9-acid is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG9-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .


IC50 & Target

PEGs

Non-cleavable


In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Liquid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month


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