[CAS NO. 17592-07-3]??Tachysterol3

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PRODUCTS SPECIFICATIONS [17592-07-3]

Catalog

HY-130705A

Brand

MCE

CAS

17592-07-3

DESCRIPTION [17592-07-3]

Overview

MDL	-
Molecular Weight	384.64
Molecular Formula	C27H44O
SMILES	O[C@@H]1CC(/C=C/C2=CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]23[H])=C(C)CC1

For research use only. We do not sell to patients.

Summary

Tachysterol 3 is a photoproduct of Previtamin D ₃ (HY-130705) ^[1] ^[2] .

IC50 & Target

Human Endogenous Metabolite

In Vitro

Tachysterol 3 can be hydroxylated by CYP11A1 and CYP27A1 ^[2] .
Tachysterol 3 is detected in human serum at a concentration of 7.3?±?2.5 ng/mL ^[2] .
Tachysterol 3 hydroxyderivatives show high-affinity binding to the ligan-binding domain (LBD) of the liver X receptor (LXR) α and β, and the peroxisome proliferator-activated receptor γ (PPARγ) in LanthaScreen TR-FRET coactivator assays ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Oil

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

* The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 130 mg/mL ( 337.98 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5998 mL	12.9992 mL	25.9983 mL
5 mM	0.5200 mL	2.5998 mL	5.1997 mL
10 mM	0.2600 mL	1.2999 mL	2.5998 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 3.25 mg/mL (8.45 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 3.25 mg/mL (8.45 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 3.25 mg/mL (8.45 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Cecilia Cisneros, et al. The Role of Tachysterol in Vitamin D Photosynthesis - A Non-Adiabatic Molecular Dynamics Study. Phys Chem Chem Phys. 2017 Feb 22;19(8):5763-5777.
[2] Slominski AT, et al. Metabolic activation of tachysterol3 to biologically active hydroxyderivatives that act on VDR, AhR, LXRs, and PPARγ receptors. FASEB J. 2022 Aug;36(8):e22451.

Synonyms

3-Cyclohexen-1-ol, 3-[(1E)-2-[(1R,3aR,7aR)-1-[(1R)-1,5-dimethylhexyl]-2,3,3a,6,7,7a-hexahydro-7a-methyl-1H-inden-4-yl]ethenyl]-4-methyl-, (1S)-

Tachysterol₃

9,10-Secocholesta-5(10),6,8-trien-3-ol, (3β,6E)-

(1S)-3-[(1E)-2-[(1R,3aR,7aR)-1-[(1R)-1,5-Dimethylhexyl]-2,3,3a,6,7,7a-hexahydro-7a-methyl-1H-inden-4-yl]ethenyl]-4-methyl-3-cyclohexen-1-ol

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