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[CAS NO. 19186-35-7]??Deoxypodophyllotoxin

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PRODUCTS SPECIFICATIONS [19186-35-7]

Catalog
HY-N2500
Brand
MCE
CAS
19186-35-7

DESCRIPTION [19186-35-7]

Overview

MDL-
Molecular Weight398.41
Molecular FormulaC22H22O7
SMILESO=C1[C@]2([H])[C@H](C3=CC(OC)=C(OC)C(OC)=C3)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1

For research use only. We do not sell to patients.

Summary

Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris . Deoxypodophyllotoxin, targets the microtubule , has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis [1] . Deoxypodophyllotoxin induces cell autophagy and apoptosis [2] . Deoxypodophyllotoxin evokes increase of intracellular Ca 2+ concentrations in DRG neurons [3] .


In Vitro

Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively [1] .
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners [1] .
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis [1]

Cell Line: SGC-7901 cells
Concentration: 25, 50, 75 nM
Incubation Time: 6, 12, 24, 48 hours
Result: Induced apoptosis in SGC-7901 Cells.

Cell Cycle Analysis [1]

Cell Line: SGC-7901 cells
Concentration: 25, 50, 75 nM
Incubation Time: 6, 12, 24, 48 hours
Result: Induced G2/M cell cycle arrest in SGC-7901 Cells

Western Blot Analysis [1]

Cell Line: SGC-7901 cells
Concentration: 25, 50, 75 nM
Incubation Time: 6, 12, 24, 48 hours
Result: Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins.

In Vivo

Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xenograft model of gastric cancer in nude mice with SGC-7901 cells [1]
Dosage: 5, 10, and 20 mg/kg
Administration: Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days
Result: Inhibited the growth of gastric cancer tumors.

Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 251.00 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5100 mL 12.5499 mL 25.0998 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL
10 mM 0.2510 mL 1.2550 mL 2.5100 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-
Podophyllotoxin, deoxy-
Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, [5R-(5α,5aβ,8aα)]-
(5R,5aR,8aR)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
Deoxypodophyllotoxin
Desoxypodophyllotoxin
Anthricin
Silicicolin
4-Deoxypodophyllotoxin
(-)-Deoxypodophyllotoxin
(-)-Anthricin
AS 2-3
(-)-Desoxypodophyllotoxin

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