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[CAS NO. 1991986-30-1]??ML364

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PRODUCTS SPECIFICATIONS [1991986-30-1]

Catalog
SLK-S6748
Brand
Selleck
CAS
1991986-30-1

DESCRIPTION [1991986-30-1]

Overview

MDL-
Molecular Weight517.54
Molecular FormulaC24H18F3N3O3S2
SMILESO=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.9322 mL9.6611 mL19.3222 mL
5 mM0.3864 mL1.9322 mL3.8644 mL
10 mM0.1932 mL0.9661 mL1.9322 mL
50 mM0.0386 mL0.1932 mL0.3864 mL

Description

ML364 is a small molecule inhibitor of the with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.

Targets

USP8 [1]
(Cell-free assay)
USP2 [1]
(Cell-free assay)
0.95 μM1.1 μM

In vitro

ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest in Mino and HCT116 cancer cell lines. ML364 is antiproliferative in cancer cell lines. ML364 also causes a decrease in homologous recombination-mediated DNA repair. It is inactive against caspase 6, caspase 7, MMP1, MMP9, and USP15, but does inhibit USP8 with an IC50 of 0.95 μM. In a panel of 102 kinases that included regulators of the cell cycle there is no binding observed to any of the enzymes tested using 10 μM ML364.


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