[CAS NO. 2135-17-3]??Flumethasone

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PRODUCTS SPECIFICATIONS [2135-17-3]

Catalog

HY-B1051

Brand

MCE

CAS

2135-17-3

DESCRIPTION [2135-17-3]

Overview

MDL	-
Molecular Weight	410.45
Molecular Formula	C22H28F2O5
SMILES	C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Drug Test Anal. 2020 Aug 27.

Summary

Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 243.64 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4364 mL	12.1818 mL	24.3635 mL
5 mM	0.4873 mL	2.4364 mL	4.8727 mL
10 mM	0.2436 mL	1.2182 mL	2.4364 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-

Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-

(6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

U 10974

6α,9α-Difluoro-16α-methylprednisolone

6α,9-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Flumethasone

6α-Fluorodexamethasone

6α,9α-Difluoro-16α-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

Flumethason

Aniprime

Flucort

Methagon

Anaprime

Flucorticin

Fluvet

RS 2177

Cortexillar

Flumetasone

Vecort

6α-Fluorodexamethazone

Aniprome

NSC 5402

NSC 54702

Flutamethasone

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