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[CAS NO. 221877-54-9]??Zotarolimus (ABT-578)

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PRODUCTS SPECIFICATIONS [221877-54-9]

Catalog
SLK-S7091
Brand
Selleck
CAS
221877-54-9

DESCRIPTION [221877-54-9]

Overview

MDL-
Molecular Weight966.21
Molecular FormulaC52H79N5O12
SMILESO(C)[C@H]1[C@](CC[C@@H](C[C@@H](C)[C@]2(OC(=O)[C@]3(N(C(=O)C(=O)[C@]4(O)O[C@](C[C@H](OC)\C(\C)=C\C=C\C=C\[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)\C(\C)=C\[C@@H](C)C(=O)C2)(CC[C@H]4C)[H])CCCC3)[H])[H])C1)(N5C=NN=N5)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.0350 mL5.1749 mL10.3497 mL
5 mM0.2070 mL1.0350 mL2.0699 mL
10 mM0.1035 mL0.5175 mL1.0350 mL
50 mM0.0207 mL0.1035 mL0.2070 mL

Description

Zotarolimus (ABT-578,A 179578) is an analogue of rapamycin, and inhibits binding with of 2.8 nM.

Features

Zotarolimus has a shorter in vivo half-life and is also demonstrated in rats to have less potent systemic immunosuppression than rapamycin.

Targets

FKBP-12 [1]
2.8 nM

In vitro

Zotarolimus (ABT-578) is a semi-synthetic analogue of rapamycin, made by substituting a tetrazole ring for the native hydroxyl group at position 42 in rapamycin. Zotarolimus is highly effective in inhibiting both smooth muscle cell and endothelial cell proliferation, with IC50 values of 2.9 nM and 2.6 nM, respectively. Zotarolimus is mechanistically similar to sirolimus in having high-affinity binding to the immunophilin FKBP12 and comparable potency for inhibiting in vitro proliferation of both human and rat T cells. Zotarolimus inhibits Con A-induced human T cells and rat T cells proliferation with IC50 of 7.0 nM and 1337 nM respectively.


Synonyms

Rapamycin, 42-deoxy-42-(1H-tetrazol-1-yl)-, (42S)-
(42S)-42-Deoxy-42-(1H-tetrazol-1-yl)rapamycin
A 179578
ABT 578
Zotarolimus
42-(1-Tetrazolyl)rapamycin
Resolute
Endeavor

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