[CAS NO. 2373-89-9]??4,4'-Dimethoxychalcone
PRODUCTS SPECIFICATIONS [2373-89-9]
DESCRIPTION [2373-89-9]
Overview
| MDL | MFCD00025815 |
|---|---|
| Molecular Weight | 268.31 |
| Molecular Formula | C17H16O3 |
| SMILES | O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=C(OC)C=C2 |
Summary
IC50 & Target
Autophagy [1]
In Vivo
The flavonoid 4,4'-Dimethoxychalcone acts as an anti-ageing compound with cardioprotective effects in mice and the potential to promote longevity across species
[1]
.
4,4'-Dimethoxychalcone (100?mg/kg; intraperitoneally) efficiently triggered autophagic flux in the heart and liver from wild type (WT) C57BL/6 mice
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 6-week-old male wild type C57BL/6 or Atg4b -/- mice [1] |
| Dosage: | 100?mg/kg |
| Administration: | Injected intraperitoneally with a single |
| Result: | Triggered autophagic flux in the heart and liver. |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 250 mg/mL ( 931.76 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7270 mL | 18.6352 mL | 37.2703 mL |
| 5 mM | 0.7454 mL | 3.7270 mL | 7.4541 mL |
| 10 mM | 0.3727 mL | 1.8635 mL | 3.7270 mL |
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1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 6.25 mg/mL (23.29 mM); Clear solution
Synonyms