[CAS NO. 24735-18-0]??Leonurine hydrochloride
PRODUCTS SPECIFICATIONS [24735-18-0]
DESCRIPTION [24735-18-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 347.79 |
| Molecular Formula | C14H22ClN3O5 |
| SMILES | O=C(OCCCCNC(N)=N)C1=CC(OC)=C(O)C(OC)=C1.[H]Cl |
3 Publications Citing Use of MCE
Summary
Leonurine hydrochloride is an alkaloid isolated from Leonurus artemisia , with anti-oxidative and anti-inflammatory.
In Vitro
Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ [1] . Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24?h. Leonurine hydrochloride (125, 250, 500?μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway [2] . Leonurine (5, 10, 20?μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice [1] . Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice [2] . Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 31 mg/mL ( 89.13 mM )
H 2 O : 5 mg/mL ( 14.38 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8753 mL | 14.3765 mL | 28.7530 mL |
| 5 mM | 0.5751 mL | 2.8753 mL | 5.7506 mL |
| 10 mM | 0.2875 mL | 1.4376 mL | 2.8753 mL |
References
- [1] Jiang T, et al. Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Pparγ/Lxrα Signaling Pathway-Dependent Manner. Cell Physiol Biochem. 2017;43(4):1703-1717.
- [2] Zhang L, et al. Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway. Biomed Pharmacother. 2018 Dec 7;110:571-581.
- [3] Hu ZC, et al. Inhibition of PI3K/Akt/NF-κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies. J Cell Physiol. 2018 Nov 11.