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[CAS NO. 2921-57-5]??Methylprednisolone succinate

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PRODUCTS SPECIFICATIONS [2921-57-5]

Catalog
HY-B1900
Brand
MCE
CAS
2921-57-5

DESCRIPTION [2921-57-5]

Overview

MDL-
Molecular Weight474.54
Molecular FormulaC26H34O8
SMILESC[C@@]12[C@](C(COC(CCC(O)=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])C[C@H](C)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

For research use only. We do not sell to patients.

Summary

Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.


IC50 & Target

glucocorticoid receptor [1]


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT04979650 Mazandaran University of Medical Sciences
Multiple Sclerosis, Relapsing-Remitting|Magnetic Resonance Imaging|Methylprednisolone
May 22, 2021 Phase 2

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 210.73 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1073 mL 10.5365 mL 21.0730 mL
5 mM 0.4215 mL 2.1073 mL 4.2146 mL
10 mM 0.2107 mL 1.0537 mL 2.1073 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-
Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-(hydrogen succinate)
Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-(H succinate)
Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-succinate
(6α,11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
6α-Methylprednisolone hemisuccinate
6-Methylprednisolone hemisuccinate
6α-Methylprednisolone 21-succinate
Methylprednisolone succinate
Methylprednisolone 21-hemisuccinate
Methylprednisolone hemisuccinate

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