一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

[CAS NO. 346640-08-2]??CCF642

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [346640-08-2]

Catalog
SLK-S8281
Brand
Selleck
CAS
346640-08-2

DESCRIPTION [346640-08-2]

Overview

MDL-
Molecular Weight378.45
Molecular FormulaC15H10N2O4S3
SMILESO=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.6424 mL13.2118 mL26.4236 mL
5 mM0.5285 mL2.6424 mL5.2847 mL
10 mM0.2642 mL1.3212 mL2.6424 mL
50 mM---

Description

CCF642 (AC1LYELL) is a novel compound with antimyeloma activity.

Targets

protein disulfide isomerases [1]

In vitro

In vitro, CCF642 inhibits PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. Computational modeling suggests a novel covalent binding mode in active-site CGHCK motifs. CCF642 causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release.

In vivo

CCF642 displays potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolongs the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.


宁都县| 天全县| 进贤县| 宁安市| 潼关县| 天台县| 麻江县| 遵化市| 宣城市| 许昌市| 德格县| 云南省| 容城县| 邯郸县| 左权县| 清徐县| 湘潭市| 安乡县| 乐安县| 新乡县| 玉山县| 孟州市| 于都县| 东丰县| 阿拉善左旗| 锡林郭勒盟| 绥化市| 齐河县| 西峡县| 邵阳市| 泰兴市| 乌鲁木齐县| 佛教| 军事| 沐川县| 中牟县| 鸡西市| 蒲城县| 盐津县| 萍乡市| 拜城县|