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[CAS NO. 346640-08-2]??CCF642

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PRODUCTS SPECIFICATIONS [346640-08-2]

Catalog
SLK-S8281
Brand
Selleck
CAS
346640-08-2

DESCRIPTION [346640-08-2]

Overview

MDL-
Molecular Weight378.45
Molecular FormulaC15H10N2O4S3
SMILESO=C1N(C2=CC=C(OC)C=C2)C(S/C1=C/C3=CC=C([N+]([O-])=O)S3)=S

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.6424 mL13.2118 mL26.4236 mL
5 mM0.5285 mL2.6424 mL5.2847 mL
10 mM0.2642 mL1.3212 mL2.6424 mL
50 mM---

Description

CCF642 (AC1LYELL) is a novel compound with antimyeloma activity.

Targets

protein disulfide isomerases [1]

In vitro

In vitro, CCF642 inhibits PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. Computational modeling suggests a novel covalent binding mode in active-site CGHCK motifs. CCF642 causes acute ER stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release.

In vivo

CCF642 displays potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolongs the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.


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