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[CAS NO. 3858-89-7]??Chloroprocaine hydrochloride

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PRODUCTS SPECIFICATIONS [3858-89-7]

Catalog
HY-B1604
Brand
MCE
CAS
3858-89-7

DESCRIPTION [3858-89-7]

Overview

MDL-
Molecular Weight307.22
Molecular FormulaC13H20Cl2N2O2
SMILESO=C(OCCN(CC)CC)C1=CC=C(N)C=C1Cl.[H]Cl

For research use only. We do not sell to patients.

Summary

Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC 50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve [1] .


IC50 & Target

IC50: 13 mM (Na,K-ATPase) [1]


In Vivo

In mice, the intravenous LD 50 of Chloroprocaine hydrochloride is 97 mg/kg and the subcutaneous LD 50 of Chloroprocaine hydrochloride is 950 mg/kg [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT05365074 H?pital de la Croix-Rousse|Hospices Civils de Lyon
Lower Limb Arthroplasty Under Chloroprocaine Spinal Anesthesia
January 1, 2020
NCT03882489 Centre Hospitalier Universitaire Saint Pierre|H?pital de Braine-l′Alleud
Knee Arthroscopy
April 11, 2019
NCT00845962 Université de Montréal|Centre hospitalier de l′Université de Montréal (CHUM)
Spinal Anesthesia
February 2009 Not Applicable

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)


Solvent & Solubility

In Vitro:

H 2 O : 100 mg/mL ( 325.50 mM ; Need ultrasonic)

DMSO : 83.33 mg/mL ( 271.24 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2550 mL 16.2750 mL 32.5500 mL
5 mM 0.6510 mL 3.2550 mL 6.5100 mL
10 mM 0.3255 mL 1.6275 mL 3.2550 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester, monohydrochloride
2-Chloro-4-aminobenzoic acid diethylaminoethyl ester hydrochloride
Chloroprocaine hydrochloride
2-Chloroprocaine hydrochloride
2-(Diethylamino)ethyl 4-amino-2-chlorobenzoate hydrochloride
Nesacaine hydrochloride
Chlorprocaine hydrochloride
Nesacaine

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