[CAS NO. 402615-91-2]??Fingolimod phosphate
PRODUCTS SPECIFICATIONS [402615-91-2]
DESCRIPTION [402615-91-2]
Overview
| MDL | MFCD18251416 |
|---|---|
| Molecular Weight | 387.45 |
| Molecular Formula | C19H34NO5P |
| SMILES | OCC(CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O |
Summary
Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases [1] .
In Vitro
Fingolimod phosphate prevents lymphocytes from moving out of the lymphoid organs and inhibits autoreactive lymphocytes from infiltrating the central nervous system
[1]
.
Fingolimod phosphate (0, 1, 10, 100 nM) binds S1P1 receptors to downregulate activated microglial production of such pro-inflammatory cytokines as tumor necrosis factor-a, interleukin-1β, and interleukin-6
[1]
.
Fingolimod phosphate (0, 1, 10, 100 nM) also upregulates microglial production of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.