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[CAS NO. 474-86-2]??Equilin

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PRODUCTS SPECIFICATIONS [474-86-2]

Catalog
HY-B1176
Brand
MCE
CAS
474-86-2

DESCRIPTION [474-86-2]

Overview

MDL-
Molecular Weight268.35
Molecular FormulaC18H20O2
SMILESC[C@]1([C@](CC2)([H])C3=CCC4=C(C=CC(O)=C4)[C@@]3([H])CC1)C2=O

For research use only. We do not sell to patients.

Summary

Equilin (7-Dehydroestrone) is an important member of the large group of oestrogenic substances and is chemically related to menformon (oestrone). Equilin increases the growth of cortical neurons via an NMDA receptor-dependent mechanism [1] [2] .


In Vitro

Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 372.65 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7265 mL 18.6324 mL 37.2648 mL
5 mM 0.7453 mL 3.7265 mL 7.4530 mL
10 mM 0.3726 mL 1.8632 mL 3.7265 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.32 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Estra-1,3,5(10),7-tetraen-17-one, 3-hydroxy-
Equilin
3-Hydroxyestra-1,3,5(10),7-tetraen-17-one
1,3,5,7-Estratetraen-3-ol-17-one
7-Dehydroestrone
NSC 10971

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