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[CAS NO. 475-25-2]??Hematein

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PRODUCTS SPECIFICATIONS [475-25-2]

Catalog
HY-119751
Brand
MCE
CAS
475-25-2

DESCRIPTION [475-25-2]

Overview

MDL-
Molecular Weight300.26
Molecular FormulaC16H12O6
SMILESO=C1C=C2CC3(C(C4=CC=C(C(O)=C4OC3)O)=C2C=C1O)O

For research use only. We do not sell to patients.

Summary

Hematein is a oxidation product of hematoxylin acted as a dye [1] . Hematein is an allosteric casein kinase II inhibitor with an IC 50 of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells [2] .


IC50 & Target

CKII

0.74 μM (IC 50 )


In Vitro

Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells [1] .
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells [1] .
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay [1]

Cell Line: A427 (HTB-53) cell line
Concentration: 10-100 μM
Incubation Time: 14 days
Result: Inhibited cells growth.

Apoptosis Analysis [1]

Cell Line: A427 (HTB-53) cell line
Concentration: 50 and 100 μM
Incubation Time: 48 hours
Result: Induced apoptosis in A427 lung cancer cells.

Western Blot Analysis [1]

Cell Line: A427 (HTB-53) cell line
Concentration: 50 and 100 μM
Incubation Time: 48 hours
Result: Inhibited CK2-specific Akt phosphorylation.

In Vivo

Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic BALB/c nude mice (6-week-old) [1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injections; twice a week for 6 weeks
Result: Inhibited tumor growth in A427 lung cancer cell xenografts.

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 333.04 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3304 mL 16.6522 mL 33.3045 mL
5 mM 0.6661 mL 3.3304 mL 6.6609 mL
10 mM 0.3330 mL 1.6652 mL 3.3304 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (8.33 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy-
Hematein
6a,7-Dihydro-3,4,6a,10-tetrahydroxybenz[b]indeno[1,2-d]pyran-9(6H)-one
Haematein
Hematine
NSC 7333

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