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[CAS NO. 499-75-2]??Carvacrol

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PRODUCTS SPECIFICATIONS [499-75-2]

Catalog
SLK-S3788
Brand
Selleck
CAS
499-75-2

DESCRIPTION [499-75-2]

Overview

MDLMFCD00002236
Molecular Weight150.22
Molecular FormulaC10H14O
SMILESC(C)(C)C1=CC(O)=C(C)C=C1

For research use only.

Storage

2 years -80 in solvent
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.

In vitro

Carvacrol (CVC) possesses weak antioxidant and cytotoxic activity in cultured primary rat neurons. In addition, Carvacrol has weak antioxidant properties and little anticancer potentials in rat N2a neuroblastoma cell line. Carvacrol is a novel inhibitor of transient receptor potential (TRP) channels in drosophila and mammalian. In human hepatoma HepG2 cells, Carvacrol induces cell apoptosis by selectively decreasing phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and P38; In human macrophage-like U937 cells, in response to lipopolysaccharide treatment, Carvacrol activates peroxisome proliferator-activated receptors (PPAR alpha and gamma) and suppresses cyclooxygenase-2 (COX-2) mRNA and protein expression.

In vivo

Carvacrol has the ability to protect liver against ischemia/reperfusion injury in rats. In the central nervous system, Carvacrol is regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase (AChE) activity by using phenolic hydroxyl group of carvacrol to bind to AChE and leading to a loss of function of AChE. In addition, Carvacrol is found to have an antidepressant-like effect in mice by affecting the dopaminergic system. Dietary carvacrol supplementation prevents high fat diet-induced obesity by modulating gene expressions that lead to adipogenesis and inflammation. Carvacrol crosses the blood-brain barrier easily and rapidly.


Synonyms

Phenol, 2-methyl-5-(1-methylethyl)-
Carvacrol
2-Methyl-5-(1-methylethyl)phenol
Antioxine
p-Cymen-2-ol
2-Hydroxy-p-cymene
2-Methyl-5-isopropylphenol
5-Isopropyl-2-methylphenol
5-Isopropyl-o-cresol
6-Methyl-3-isopropylphenol
2-Hydroxy-1-methyl-4-(1-methylethyl)benzene
3-Isopropyl-6-methylphenol
Isopropyl o-cresol
Isothymol
NSC 6188
Dentol
2-Methyl-5-(propan-2-yl)phenol

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