[CAS NO. 50-34-0]??Propantheline bromide
PRODUCTS SPECIFICATIONS [50-34-0]
DESCRIPTION [50-34-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 448.39 |
| Molecular Formula | C23H30BrNO3 |
| SMILES | CC([N+](C(C)C)(C)CCOC(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)=O)C.[Br-] |
Summary
IC50 & Target
mAChR [1]
In Vitro
Propantheline bromide (10 μM-1 mM) decreases urinary bladder smooth muscle reactivity to Acetylcholine
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Propantheline bromide (oral administration, 10-300 mg/kg) decreased the fecal pellet count and the incidences diarrhea in restraint stress-induced bowel dysfunction rats [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Restraint stress-induced bowel dysfunction models in rats [3] |
| Dosage: | 10-300 mg/kg |
| Administration: | Oral administration |
| Result: |
Decreased the fecal pellet count with ED
50
values of 41 mg/kg.
Dose-dependently decreased the incidences of diarrhea with ED50 values of 64 mg/kg. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01640002 | Hospital Universitário Professor Edgard Santos |
Overactive Bladder Associated With HTLV-1
|
May 2012 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 223.02 mM )
H 2 O : 50 mg/mL ( 111.51 mM ; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2302 mL | 11.1510 mL | 22.3020 mL |
| 5 mM | 0.4460 mL | 2.2302 mL | 4.4604 mL |
| 10 mM | 0.2230 mL | 1.1151 mL | 2.2302 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 130 mg/mL (289.93 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (5.58 mM); Clear solution
References
- [1] J Mokry, et al. Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs. Bratisl Lek Listy. 2005;106(4-5):151-4.
- [2] Richard Jewell, et al. Propantheline. xPharm: The Comprehensive Pharmacology Reference. 2007, Pages 1-5.
- [3] S Kobayashi, et al. Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo. Jpn J Pharmacol. 2001 Jul;86(3):281-8.
Synonyms