[CAS NO. 521-32-4]??Bilobetin
PRODUCTS SPECIFICATIONS [521-32-4]
DESCRIPTION [521-32-4]
Overview
| MDL | MFCD00597036 |
|---|---|
| Molecular Weight | 552.48 |
| Molecular Formula | C31H20O10 |
| SMILES | O=C1C=C(C2=CC=C(O)C=C2)OC3=C(C4=CC(C5=CC(C6=C(O)C=C(O)C=C6O5)=O)=CC=C4OC)C(O)=CC(O)=C13 |
Summary
Bilobetin, an active component of Ginkgo biloba , can reduce blood lipids and improve the effects of insulin . Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity [1] .
IC50 & Target
|
PPARα |
PKA |
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 250 mg/mL ( 452.51 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.8100 mL | 9.0501 mL | 18.1002 mL |
| 5 mM | 0.3620 mL | 1.8100 mL | 3.6200 mL |
| 10 mM | 0.1810 mL | 0.9050 mL | 1.8100 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.08 mg/mL (3.76 mM); Suspended solution; Need ultrasonic
Synonyms