[CAS NO. 522-97-4]??Tetrahydroberberine

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PRODUCTS SPECIFICATIONS [522-97-4]

Catalog

HY-N0925

Brand

MCE

CAS

522-97-4

DESCRIPTION [522-97-4]

Overview

MDL	-
Molecular Weight	339.39
Molecular Formula	C20H21NO4
SMILES	COC1=CC=C(CC23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC

For research use only. We do not sell to patients.

Summary

Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 73.66 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9465 mL	14.7323 mL	29.4646 mL
5 mM	0.5893 mL	2.9465 mL	5.8929 mL
10 mM	0.2946 mL	1.4732 mL	2.9465 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
[2] Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.

Synonyms

6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-

Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)-

Berberine, 9-deoxy-16,17-dihydro-

5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine

Berberine, tetrahydro-

Tetrahydroberberine

Xanthopuccine

Canadine

Tetrahydroumbellatine

(±)-Canadine

(±)-Tetrahydroberberine

dl-Tetrahydroberberine

dl-Canadine

NSC 36351

NSC 94918

Tetrahydroberineper

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