[CAS NO. 52809-07-1]??Quisqualicacid
PRODUCTS SPECIFICATIONS [52809-07-1]
DESCRIPTION [52809-07-1]
Overview
| MDL | MFCD00069337 |
|---|---|
| Molecular Weight | 189.13 |
| Molecular Formula | C5H7N3O5 |
| SMILES | O=C(O)[C@@H](N)CN(C(N1)=O)OC1=O |
Summary
IC50 & Target
|
mGluR1R 45 nM (EC 50 ) |
mGluR1R 10 nM (Ki) |
mGluR2R 108 μM (IC 50 ) |
mGluR2R 113 μM (Ki) |
mGluR4R 593 μM (IC 50 ) |
mGluR4R 112 μM (Ki) |
In Vitro
Quisqualic acid is an agonist of AMPA and metabotropic glutamate receptors. Quisqualic acid activates mGluR2R (EC 50 =108 μM; K i =113 μM) and mGluR4R (EC 50 =593 μM; K i =112 μM) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 12.5 mg/mL ( 66.09 mM ; ultrasonic and warming and heat to 60°C)
H 2 O : 2 mg/mL ( 10.57 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.2874 mL | 26.4368 mL | 52.8737 mL |
| 5 mM | 1.0575 mL | 5.2874 mL | 10.5747 mL |
| 10 mM | 0.5287 mL | 2.6437 mL | 5.2874 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (132.18 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1.25 mg/mL (6.61 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 1.25 mg/mL (6.61 mM); Clear solution
References
- [1] Hugues-Olivier Bertrand, et al. Common and Selective Molecular Determinants Involved in Metabotopic Glutamate Receptor Agonist Activity. J Med Chem. 2002 Jul 18;45(15):3171-83.
- [2] H Br?uner-Osborne, et al. Ligands for Glutamate Receptors: Design and Therapeutic Prospects. J Med Chem. 2000 Jul 13;43(14):2609-45.
Synonyms