[CAS NO. 529-84-0]??4-Methylesculetin

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PRODUCTS SPECIFICATIONS [529-84-0]

Catalog

HY-N4288

Brand

MCE

CAS

529-84-0

DESCRIPTION [529-84-0]

Overview

MDL	-
Molecular Weight	192.17
Molecular Formula	C10H8O4
SMILES	O=C1C=C(C)C2=CC(O)=C(O)C=C2O1

For research use only. We do not sell to patients.

Summary

4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 260.19 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2037 mL	26.0186 mL	52.0373 mL
5 mM	1.0407 mL	5.2037 mL	10.4075 mL
10 mM	0.5204 mL	2.6019 mL	5.2037 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (13.01 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (10.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (10.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Witaicenis A, et al. 4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation. Chem Biol Interact. 2018 Jan 25;280:59-63.

Synonyms

2H-1-Benzopyran-2-one, 6,7-dihydroxy-4-methyl-

Coumarin, 6,7-dihydroxy-4-methyl-

Esculetin, 4-methyl-

6,7-Dihydroxy-4-methyl-2H-1-benzopyran-2-one

4-Methylesculetin

4-Methyl-6,7-dihydroxycoumarin

4-Methylaesculetin

6,7-Dihydroxy-4-methylcoumarin

Methylesculetin

4-Methylesculetol

NSC 11828

NSC 688807

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