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[CAS NO. 5302-45-4]??Dencichine

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PRODUCTS SPECIFICATIONS [5302-45-4]

Catalog
HY-N1477
Brand
MCE
CAS
5302-45-4

DESCRIPTION [5302-45-4]

Overview

MDLMFCD00055228
Molecular Weight176.13
Molecular FormulaC5H8N2O5
SMILESN[C@@H](CNC(C(O)=O)=O)C(O)=O

For research use only. We do not sell to patients.

Summary

Dencichin is a non-protein amino acid originally extracted from Panax notoginseng , and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.


IC50 & Target

PHD-2 [1]


In Vitro

Dencichin (β-ODAP, 10 μM, 50 μM, 100 μM and 200 μM) increases HRE expression by 1.3±0.09, 2.5±0.07, 4.2±0.15 and 1.3±0.07 fold respectively compared to control. Dencichin has intermolecular interactions with PHD-2 [1] . Dencichin (10 μM, 100 μM, 1 mM) significantly inhibits cell proliferation and extracellular matrix (ECM) proteins accumulation of HBZY-1 cells, and reduces the secretion of collagen I (Col I), collagen IV (Col IV), and fibronectin (FN) [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

Dencichin improves metabolism disorder in diabetic nephropathy (DN) secondary to type II diabetes mellitus (DM) model. Dencichin (80, 160 mg/kg/day, p.o.) significantly prevents the up-regulation of TCH, TG, LDL, and HbAlc and the down-regulation of HDL in DN rats induced by STZ injection. Dencichin also attenuates renal injury induced in the DN secondary to type II DM model. Dencichin alleviates pancreas damage in the STZ-induced DN model. Dencichin regulates protein expression in the TGF-β/Smad signalling pathway in STZ-induced DN models [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL ( 28.39 mM ; Need ultrasonic)

H 2 O : 5 mg/mL ( 28.39 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6776 mL 28.3881 mL 56.7762 mL
5 mM 1.1355 mL 5.6776 mL 11.3552 mL
10 mM 0.5678 mL 2.8388 mL 5.6776 mL
* Please refer to the solubility information to select the appropriate solvent.


Synonyms

L-Alanine, 3-[(carboxycarbonyl)amino]-
Oxamic acid, (2-amino-2-carboxyethyl)-, L-
3-[(Carboxycarbonyl)amino]-L-alanine
β-N-Oxalyl-L-α,β-diaminopropionate
β-N-Oxalyl-L-α,β-diaminopropionic acid
BOAA
Nβ-Oxalylamino-L-alanine
Neurotoxin (Lathyrus sativus)
L-3-Oxalylamino-2-aminopropionic acid
Dencichin
L-Dencichin
3-N-Oxalyl-L-2,3-diaminopropanoic acid
ODAP
β-N-Oxalo-L-α,β-diaminopropionic acid
3-N-Oxalyl-L-2,3-diaminopropionic acid
Dencichine
(S)-2-Amino-3-(carboxyformamido)propanoic acid
(2S)-2-Amino-3-(carboxyformamido)propanoic acid

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