[CAS NO. 534-13-4]??N,N'-Dimethylthiourea
PRODUCTS SPECIFICATIONS [534-13-4]
DESCRIPTION [534-13-4]
Overview
| MDL | MFCD00004923 |
|---|---|
| Molecular Weight | 104.17 |
| Molecular Formula | C3H8N2S |
| SMILES | S=C(NC)NC |
Summary
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum , is an orally active scavenger of hydroxyl radical (?OH) and blocks ?OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including ?OH scavenging and anti-inflammatory action [1] [2] .
In Vivo
N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 959.97 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 9.5997 mL | 47.9985 mL | 95.9969 mL |
| 5 mM | 1.9199 mL | 9.5997 mL | 19.1994 mL |
| 10 mM | 0.9600 mL | 4.7998 mL | 9.5997 mL |
References
Synonyms