[CAS NO. 5351-17-7]??4-Aminobenzohydrazide

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PRODUCTS SPECIFICATIONS [5351-17-7]

Catalog

HY-B0880

Brand

MCE

CAS

5351-17-7

DESCRIPTION [5351-17-7]

Overview

MDL	MFCD00007606
Molecular Weight	151.17
Molecular Formula	C7H9N3O
SMILES	O=C(NN)C1=CC=C(N)C=C1

For research use only. We do not sell to patients.

Summary

4-Aminobenzohydrazide is an irreversible MPO myeloperoxidase inhibitor with an IC ₅₀ of 0.3 μM ^[1] . It is used for the research of subacute stroke ^[2] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 25 mg/mL ( 165.38 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.6151 mL	33.0753 mL	66.1507 mL
5 mM	1.3230 mL	6.6151 mL	13.2301 mL
10 mM	0.6615 mL	3.3075 mL	6.6151 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1 mg/mL (6.62 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1 mg/mL (6.62 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kettle AJ, et al. Inhibition of myeloperoxidase by benzoic acid hydrazides. Biochem J. 1995 Jun 1;308 ( Pt 2)(Pt 2):559-63.
[2] Forghani R, et al. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar;35(3):485-93.

Synonyms

Benzoic acid, 4-amino-, hydrazide

Benzoic acid, p-amino-, hydrazide

p-Aminobenzoic acid hydrazide

p-Aminobenzhydrazide

Amben hydrazide

p-Aminobenzoic hydrazide

4-Aminobenzhydrazide

4-Aminobenzoic acid hydrazide

4-Aminobenzoylhydrazine

p-Aminobenzoylhydrazine

Aminostimil

4-Aminobenzoyl hydrazide

NSC 640

p-Aminobenzohydrazide

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