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[CAS NO. 54857-86-2]??TOFA

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PRODUCTS SPECIFICATIONS [54857-86-2]

Catalog
HY-101068
Brand
MCE
CAS
54857-86-2

DESCRIPTION [54857-86-2]

Overview

MDLMFCD01726059
Molecular Weight324.45
Molecular FormulaC19H32O4
SMILESO=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)O

For research use only. We do not sell to patients.


Summary

TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α ( ACCA ).


In Vitro

TOFA (5-tetradecyloxy-2-furoic acid) is cytotoxic to lung cancer cells NCI-H460 and colon carcinoma cells HCT-8 and HCT-15, with an IC 50 at approximately 5.0, 5.0, and 4.5 μg/mL, respectively. TOFA at 1.0–20.0 μg/mL effectively blocks fatty acid synthesis and induces cell death in a dose-dependent manner [1] . TOFA is found to be cytotoxic to COC1 and COC1/DDP cells with IC 50 values of ~26.1 and 11.6 μg/mL, respectively. TOFA inhibits the proliferation of the cancer cells examined in a time and dose dependent manner, arrests the cells in the G0/G1 cell cycle phase and induces apoptosis [2] . Acetyl-CoA-carboxylase-α (ACCA) is a key enzyme in the regulation of fatty acids synthesis. Inhibition of ACCA by TOFA decreases fatty acid synthesis and induces caspase activation and cell death in most PCa cell lines [3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi?cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm 3 . No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 11.36 mg/mL ( 35.01 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0821 mL 15.4107 mL 30.8214 mL
5 mM 0.6164 mL 3.0821 mL 6.1643 mL
10 mM 0.3082 mL 1.5411 mL 3.0821 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 1.14 mg/mL (3.51 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

2-Furancarboxylic acid, 5-(tetradecyloxy)-
5-(Tetradecyloxy)-2-furancarboxylic acid
RMI 14514
5-(Tetradecyloxy)-2-furoic acid
RMI 14,514
MDL 14514

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