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[CAS NO. 54965-21-8]??Albendazole (SKF-62979)

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PRODUCTS SPECIFICATIONS [54965-21-8]

Catalog
SLK-S1640
Brand
Selleck
CAS
54965-21-8

DESCRIPTION [54965-21-8]

Overview

MDL-
Molecular Weight265.33
Molecular FormulaC12H15N3O2S
SMILESN(C(OC)=O)C=1NC=2C(N1)=CC(SCCC)=CC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM3.7689 mL18.8445 mL37.6889 mL
5 mM0.7538 mL3.7689 mL7.5378 mL
10 mM0.3769 mL1.8844 mL3.7689 mL
50 mM0.0754 mL0.3769 mL0.7538 mL

Description

Albendazole (SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.

Targets

tubulin [1]

In vitro

Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle.

In vivo

Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs.


Synonyms

Carbamic acid, N-[6-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
Carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester
Methyl 5-propylthio-2-benzimidazolecarbamate
Albendazole
SKF 62979
Valbazen
Vermitan
Alzental
Albamelin
Zentel
NSC 220008
Albenza
Haojing
Eskazole
Exiptol
Albendol
Alminth
Tobend
Atasol
Andazol
Vermizole
Bruzol
Helminsols
Loveral
Albenzil
Lurdex
Vermisen
Ashialben
Vetalben
Baxen
Aldifal
Alben
Alvet
(6-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester
(5-Propylsulfanyl-1,3-dihydro-benzoimidazol-2-ylidene)-carbamic acid methyl ester

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