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[CAS NO. 56973-41-2]??WithanolideB

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PRODUCTS SPECIFICATIONS [56973-41-2]

Catalog
HY-129566
Brand
MCE
CAS
56973-41-2

DESCRIPTION [56973-41-2]

Overview

MDL-
Molecular Weight454.60
Molecular FormulaC28H38O5
SMILESC[C@@]12[C@]3([H])[C@@]([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H]([C@@]5([H])CC(C)=C(C(O5)=O)C)C)C)([H])[C@H]6[C@@H]([C@]1(CC=CC2=O)O)O6

For research use only. We do not sell to patients.

Summary

Withanolide B is an active component of W. somnifera Dunal . Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways . Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects [1] [2] [3] .


In Vitro

Withanolide B (1-100 nM; 3-5 days) significantly increases the expression of COL1A1 and RUNX2 genes and proteins in hBMSCs [1] .
Withanolide B (1-100 nM; 11 or 3 days) increases the formation of extracellular matrix calcium deposits and increased the activity of alkaline phosphatase (ALP) [1] .
Withanolide B (1-100 nM; 3-5 days) increases the protein expressions of p-ERK and active β-catenin of hBMSCs [1] .
Withanolide B (10-100 μM; 48 h) reverses the Aβ42 aggregation-induced toxicy in SK-N-SH cells [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay [1]

Cell Line: Human bone mesenchymal stem cells
Concentration: 1, 10, 100 nM
Incubation Time: 3, 5 days
Result: Significantly increased the expression of COL1A1 and RUNX2.

In Vivo

Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect [1]
Dosage: 10 mg/kg
Administration: Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result: Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.

Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month


Synonyms

Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,22-dihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-
Withanolide B
Lycium substance B

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