[CAS NO. 57-13-6]??Urea

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PRODUCTS SPECIFICATIONS [57-13-6]

Catalog

HY-Y0271

Brand

MCE

CAS

57-13-6

DESCRIPTION [57-13-6]

Overview

MDL	MFCD00008022
Molecular Weight	60.06
Molecular Formula	CH4N2O
SMILES	NC(N)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Autophagy. 2022 Nov 30.

Summary

Urea is a powerful protein denaturant via both direct and indirect mechanisms ^[1] . A potent emollient and keratolytic agent ^[2] . Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function ^[3] . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

IC50 & Target

Microbial Metabolite

Human Endogenous Metabolite

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04612595	Guangdong Provincial People′s Hospital	Diabetic Kidney Disease	August 1, 2018
NCT00667589	Northwestern University\|Bayer	Hand-foot Skin Reaction\|Rash	June 2008	Phase 2
NCT04982133	Hospital Universitario La Paz	Preterm\|Very Low Birth Weight Infant\|Feeding, Breast\|Food, Fortified	April 19, 2021	Not Applicable
NCT00005889	National Center for Research Resources (NCRR)\|Baylor College of Medicine	Infant, Low Birth Weight\|Hyperglycemia	October 1999	Not Applicable
NCT00576238	ACO Hud Nordic AB	Atopic Eczema	January 2004	Phase 3
NCT01376414	George Washington University	Gastritis\|Peptic Ulcer\|Peptic Ulcer Perforation\|Stomach Ulcer	March 2011
NCT05028335	Universidade Federal do Para	Dentin Sensitivity	December 7, 2020	Not Applicable
NCT04127513	Indonesia University	Xerosis Cutis	April 1, 2017	Phase 3
NCT02247830	University of Brasilia	Radiodermatitis	July 2015	Phase 3
NCT01838265	University of Miami	Prostate Cancer\|Prostate Adenocarcinoma	August 2012
NCT00576550	ACO Hud Nordic AB\|Smerud Medical Research International AS	Hand Eczema	October 2007	Phase 4
NCT02017873	University of Chile	Dentin Sensitivity	December 2013	Phase 4
NCT05024864	Karolinska Institutet\|The Swedish Research Council\|Swedish Heart Lung Foundation\|Region Stockholm	Myocardial Infarction\|Helicobacter Pylori Infection\|GastroIntestinal Bleeding\|Cardiovascular Diseases	November 17, 2021	Not Applicable
NCT03469544	Assiut University	Thyroid Cancer	March 29, 2018
NCT02682329	Universidad Iberoamericana	Tooth Stain	February 2014	Phase 4
NCT04892238	Federal State Budgetary Scientific Institution Federal Research Centre of Nutrition, Biotechnology\|Moscow Clinical Scientific Center\|St. Petersburg State Pavlov Medical University\|People′s Friendship University of Russia	Helicobacter Pylori Infection	January 1, 2017
NCT05046015	Galderma R&D	Xerosis Cutis	September 2016	Not Applicable
NCT01626781	AIO-Studien-gGmbH	the Treatment Hand-foot Syndrome Patients With Gastrointestinal Tumors or Breast Cancer, Who Are Treated With Capecitabine
NCT03376620	University of Manitoba	Hypertrophic Scar	September 2, 2011	Phase 3
NCT02111655	Hospital Infanta Sofia	Thrombosis	September 1, 2012	Not Applicable
NCT04923113	Second Affiliated Hospital, School of Medicine, Zhejiang University	Helicobacter Pylori Infection	June 15, 2021	Not Applicable
NCT02935114	Universidade Federal de Sergipe	Tooth Sensitivity	May 2016	Phase 3
NCT02249884	University of Brasilia\|University of Washington	Radiodermatitis	February 2014	Phase 2
NCT02816593	Federal University of Minas Gerais	Discolored Teeth	August 2015	Not Applicable
NCT00197457	Hamamatsu University	H. Pylori Infection\|Gastric Ulcer\|Duodnal Ulcer	June 2001	Phase 2
NCT03212625	Korea University Guro Hospital\|Hanmi Pharmaceutical Company Limited	Hepatocellular Carcinoma	January 28, 2016	Phase 4
NCT03397680	Thammasat University	Helicobacter Pylori Infection	May 15, 2017	Phase 1
NCT04994951	The First Affiliated Hospital of Zhejiang Chinese Medical University\|Pujiang Hospital of Traditional Chinese Medicine\|Yongkang Hospital of Traditional Chinese Medicine\|Ningbo Hospital of Traditional Chinese Medicine\|Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine	Psoriasis Vulgaris	September 2021	Phase 2
NCT05214872	Poznan University of Medical Sciences	Atherosclerosis of Artery\|Inflammation\|Chronic Kidney Diseases\|Dialysis; Complications\|Cardiovascular Diseases	March 25, 2016
NCT01342939	University Hospital, Gentofte, Copenhagen\|University of Copenhagen\|Steno Diabetes Center Copenhagen	Maturity-onset Diabetes of the Young	January 2011
NCT03763188	Dr Alexandre Gros\|Gros, Alexandre, M.D.	Acute Kidney Injury	September 1, 2016
NCT00196443	University Medicine Greifswald\|Bauerfeind AG, Zeulenroda, Germany	Venous Insufficiency	June 2005	Phase 2\|Phase 3
NCT02111148	Beni-Suef University\|Cairo University	Disorder of Amniotic Cavity and+or Membrane	May 2014	Not Applicable
NCT03658317	Assiut University	Diabetic Nephropathy	September 2018	Not Applicable
NCT02191007	Xijing Hospital	Psoriasis	November 2013	Not Applicable
NCT02330614	University of Chile	Personality	July 2013
NCT02251392	University of Brasilia\|University of Washington\|Conselho Nacional de Desenvolvimento Científico e Tecnológico	Radiodermatitis	August 2015	Phase 3
NCT03236038	Corporacion Parc Tauli	Exocrine Pancreatic Insufficiency	October 1, 2017
NCT05276557	ARJ Medical, Inc.	Helicobacter Pylori\|Safety\|Efficacy	November 2022	Phase 3
NCT04987385	University Hospital, Basel, Switzerland	Syndrome of Inappropriate Antidiuresis (SIAD)	October 8, 2021	Not Applicable
NCT04301336	Beni-Suef University\|Benisuef university hospital\|University of Arizona\|Maternity and Children Hospital, Makkah	Vaso-occlusive Crisis\|Sickle Cell Disease\|Sickle Cell Anemia in Children	November 1, 2019	Phase 2\|Phase 3
NCT02601222	Guizhou Tongjitang Pharmaceutical Co.,Ltd\|Beijing Bionovo Medicine Development Co., Ltd.	Chronic Eczema	March 2016	Phase 4
NCT03207204	University of Sao Paulo	Tooth Bleaching\|Dentin Sensitivity	July 2, 2017	Not Applicable
NCT01303068	University of New Mexico	Cystic Fibrosis	August 2013	Not Applicable
NCT05451472	Sohag University	Chronic Renal Failure	July 1, 2022	Not Applicable
NCT05588258	Universidad Complutense de Madrid	Diabetic Foot	November 2, 2021	Not Applicable
NCT01909141	Cairo University	Polycystic Ovary Syndrome\|Infertility	August 2013	Early Phase 1
NCT03369561	Assiut University	Acute Kidney Injury (Nontraumatic)	January 1, 2018
NCT05348278	Mahidol University\|Siriraj Hospital	Hand-Foot Syndrome	December 20, 2021	Phase 2\|Phase 3
NCT02741427	Federal University of Paraíba\|Unilever R&D	Tooth Discoloration	September 2012	Phase 4
NCT02705664	Galderma R&D	Foot Dermatoses	January 2016	Phase 4
NCT04588207	Helbert Rondon Berrios, MD, MS\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|University of Pittsburgh	Hyponatremia\|Inappropriate ADH Syndrome	March 29, 2022	Phase 2
NCT05535517	Premier Specialists, Australia	Keratosis Pilaris	August 13, 2022
NCT02718183	University of Chile	Discolored Teeth	March 2015	Not Applicable
NCT04552873	University Hospital, Grenoble	Hyponatremia\|Subarachnoid Hemorrhage\|SIADH	December 3, 2020	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 1665.00 mM ; Need ultrasonic)

DMSO : 100 mg/mL ( 1665.00 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	16.6500 mL	83.2501 mL	166.5002 mL
5 mM	3.3300 mL	16.6500 mL	33.3000 mL
10 mM	1.6650 mL	8.3250 mL	16.6500 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (1665.00 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (41.63 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (41.63 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (41.63 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5142-7.
[2] Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19(11):20392.
[3] Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29.

Synonyms

Urea

Carbamide

Isourea

Carbamimidic acid

Carbonyl diamide

Urevert

Ureaphil

Ureophil

Pseudourea

B-I-K

Varioform II

Benural 70

Urepearl

Urea perhydrate

Urepeal

Keratinamin Kowa

Pastaron

Pastaron 20

Pastaron 20 soft

Urepeal L

Pastaron 10

Eucerin 10% Urea Lotion

Optigen 1200

Aquacare

Basodexan

Keratinamin

Aquadrate

Hyanit

Elaqua XX

Onychomal

Nutraplus

NSC 34375

Pastaron soft

Rubinol ST 010

Carmol 40

SGN 250

Uroderm

Ultra Low Biuret Urea

Low Biuret Urea

Duration III

ESN

Optigen II

Uria

Cellton NP

Cellpaste K 4

AUS 32

Onyster

Diesel exhaust fluid

DEF

DEF (diesel exhaust fluid)

AdBlue

U 6504

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