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[CAS NO. 66280-25-9]??Gomisin J

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PRODUCTS SPECIFICATIONS [66280-25-9]

Catalog
HY-N0385
Brand
MCE
CAS
66280-25-9

DESCRIPTION [66280-25-9]

Overview

MDLMFCD29048562
Molecular Weight388.45
Molecular FormulaC22H28O6
SMILESOC1=C(OC)C(OC)=C(C2=C(OC)C(OC)=C(O)C=C2CC(C)C(C)C3)C3=C1

For research use only. We do not sell to patients.


Summary

Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity [1] . Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK , LKB1 and Ca 2+ /calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease [2] .


IC50 & Target

AMPK


Appearance

Solid



Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 257.43 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5743 mL 12.8717 mL 25.7433 mL
5 mM 0.5149 mL 2.5743 mL 5.1487 mL
10 mM 0.2574 mL 1.2872 mL 2.5743 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.44 mM); Clear solution

* All of the co-solvents are available by MCE.


Synonyms

Dibenzo[a,c]cyclooctene-3,10-diol, 5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-, (6R,7S,12aS)-
Dibenzo[a,c]cyclooctene-3,10-diol, 5,6,7,8-tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyl-, stereoisomer
(6R,7S,12aS)-5,6,7,8-Tetrahydro-1,2,11,12-tetramethoxy-6,7-dimethyldibenzo[a,c]cyclooctene-3,10-diol
Gomisin J
(-)-Gomisin J

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